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折扣/货期| 货号：AG-CN2-0444-C100 | 规格：100 ug | 目录价：￥1560 |
| 货号：AG-CN2-0444-M001 | 规格：1 mg | 目录价：￥6960 |
| 货号：AG-CN2-0444-M005 | 规格：5 mg | 目录价：￥22800 |
| 货号：AG-CN2-0444-M050 | 规格：50 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Salinosporamide A
别名:
SalA; Marizomib; NPI-0052
产品描述:
Potent, irreversible inhibitor of all the 3 proteolytic activities of the mammalian 20S proteasome. beta5 subunit: chymotrypsin-like (EC50 = 3.5nM) beta2 subunit: trypsin-like (EC50 = 28nM) beta1 subunit: caspase-like or peptidyl-glutamyl peptide-hydrolyzing (PGPH) (EC50 = 430nM) Potent anticancer compound. Triggers apoptosis, with distinct proteasome activity and mechanism of action compared to bortezomib (Velcade) (Prod. No. AG-CR1-3602). Most potent suppressor of NF-kappaB activation, compared with bortezomib, MG-132 (Prod. No. AG-CP3-0011), N-acetyl-leucyl-leucyl-norleucinal (ALLN) and lactacystin (Prod. No. AG-CN2-0104). Inhibitor of TNF-alpha, IL-1, IL-6, ICAM-1 and VEGF synthesis. Displays a longer inhibition duration than bortezomib. Potent antileukemic activity against bortezomib-resistant leukemia cells.
宿主来源:
Isolated from Salinospora tropica.
保存温度:
+4°C
运输温度:
BI
预期分子量:
313.8
产品形式:
solid
有效期:
Stable for at least 1 year after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95% (HPLC)
CAS号:
437742-34-2
分子式:
C15H20ClNO4
溶解度:
Soluble in DMSO. Do not dissolve in methanol or ethanol.
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