SHANK1 Antibody: APC-单抗-深圳欣博盛生物科技有限公司

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SHANK1 Antibody: APC

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SMC-329D-APC

规格：100 µg

目录价：￥4914

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

SHANK1 Antibody: APC

别名:

GKAP/SAPAP interacting protein Antibody, OTTHUMP00000174437 Antibody, SH3 and multiple ankyrin repeat domains 1 Antibody, SH3 and multiple ankyrin repeat domains protein 1 Antibody, SH3/ankyrin domain gene 1 Antibody, SHAN1_HUMAN Antibody, SHANK 1 Antibody, Shank1 Antibody, Shank1a Antibody, Somatostatin receptor interacting protein Antibody, Somatostatin receptor-interacting protein Antibody, SPANK 1 Antibody, SPANK1 Antibody, SSTR interacting protein Antibody, SSTR-interacting protein Antibody, SSTRIP Antibody, Synamon Antibody

产品描述:

Mouse Anti-Rat SHANK1 Monoclonal IgG1

反应种属:

Human | Mouse | Rat

宿主来源:

Mouse

实验应用:

WB | IHC | AM

靶标/特异性:

Detects ~190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3.

同种型:

IgG1

推荐稀释度:

WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

免疫原:

Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1

免疫原种属:

Rat

克隆性:

Monoclonal

克隆号:

N22/21 (Formerly sold as S22-21)

纯化方式:

Protein G Purified

偶联:

APC

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).

Accession #:

NP_113939.2