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折扣/货期| 货号：AG-CR1-3555-M005 | 规格：5 mg | 目录价：￥360 |
| 货号：AG-CR1-3555-M025 | 规格：25 mg | 目录价：￥1440 |
| 货号：AG-CR1-3555-M100 | 规格：100 mg | 目录价：￥4320 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
SLU-PP-332
别名:
4-Hydroxy-N′-[(E)-2-naphthylmethylene]benzohydrazide
产品描述:
SLU-PP-332 is a potent and selective pan-estrogen-related receptor (ERR) agonist (EC50 values are 98 nM, 230 nM and 430 nM for ERRalpha, ERRbeta and ERRgamma respectively). SLU-PP-332 increases energy expenditure and fatty acid oxidation, decreases fat mass, and improves insulin sensitivity. It enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 decreases body weight and fat mass, blood levels of total cholesterol, HDL and triglycerides and adipocyte size in a mouse model of high-fat diet-induced obesity when administered at a dose of 50 mg/kg twice per day. It reduces blood glucose levels in a glucose tolerance test in the same animals at the same dose. Estrogen-related receptors ERRalpha and ERRgamma are essential regulators of cardiac metabolism. SLU-PP-332 significantly improved ejection fraction, ameliorated fibrosis and increased survival associated with pressure overload-induced heart failure (HF) without affecting cardiac hypertrophy.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
290.3
产品形式:
solid
产地:
瑞士
纯度:
>98%
CAS号:
303760-60-3
分子式:
C18H14N2O2
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