Soluble RANK Ligand Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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Soluble RANK Ligand Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：40-451-0.002 mg	规格：0.002 mg	目录价：￥3783
货号：40-451-0.01 mg	规格：0.01 mg	目录价：￥5674.5

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Soluble RANK Ligand Recombinant Protein

别名:

ODF, OPG, OPGL, RANKL, Ly109l, Trance, Opgl, Rankl, Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, ODF

表达系统:

E. coli

保存温度:

The lyophilized Soluble RANK Ligand recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Soluble RANK Ligand is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Soluble RANK Ligand recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

运输温度:

Blue Ice

产品形式:

Lyophilized

产地:

美国

生产商:

Prosci

功能与背景:

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant murine sRANKL is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino acid residues).

纯度:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).

生物活性:

Determined by its dose-dependent ability to induce reporter gene in HT-29 NF-κB Luc reporter cells.

Accession #:

NP_035743.2

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