STUB1 Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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STUB1 Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：91-098

规格：0.05 mg

目录价：￥9038.25

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

STUB1 Recombinant Protein

别名:

E3 Ubiquitin-Protein Ligase CHIP, Antigen NY-CO-7, CLL-Associated Antigen KW-8, Carboxy Terminus of Hsp70-Interacting Protein, STIP1 Homology and U Box-Containing Protein 1, STUB1, CHIP

表达系统:

E. coli

保存温度:

Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

运输温度:

Dry Ice

产品形式:

Liquid

存储溶液:

Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

产地:

美国

生产商:

Prosci

功能与背景:

E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.

纯度:

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

Accession #:

Q9UNE7

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