Talabostat . mesylate-其他小分子化合物-深圳欣博盛生物科技有限公司

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Talabostat . mesylate

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3541-M010	规格：10 mg	目录价：￥840
货号：AG-CR1-3541-M050	规格：50 mg	目录价：￥3360

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Talabostat . mesylate

别名:

Valinyl-L-boroproline; Val-boro-Pro; BXCL 701; PT-100; B-[(2R)-1-[(2S)-2-Amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic acid methanesulfonate

产品描述:

Talabostat is an orally bioavailable non-selective inhibitor of dipeptidyl-peptidases (DPPs), including DPP-4, DPP-7/QPP, DPP-8, DPP-9, fibroblast activation protein (FAP) and prolyl endopeptidase (PREP; PEP) (IC50s = >4, 310, 4, 11, 560 and 390 nM, respectively). Talabostat induces powerful anti-tumor immune responses in cancer models. Talabostat is a NLRP1 and caspase recruitment domain family member 8 (CARD8) inflammasome activator. Talabostat triggers an immunostimulatory form of programmed cell death known as pyroptosis selectively in monocytes and macrophages. DPP8/9 inhibition by Talabostat activates the inflammasome sensor protein Nlrp1b, which in turn activates pro-caspase-1 to mediate pyroptosis, suggesting that DPP8/9 serve as an intracellular checkpoint to restrain Nlrp1b and the innate immune system. Talabostat has anti-obesity properties and lowers body weight, blood glucose, plasma insulin and total cholesterol while improving glucose tolerance and insulin sensitivity in mouse models. It has also been shown to elevate FGF21 levels in plasma.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

310.2

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)