官网链接
折扣/货期| 货号：11-080 | 规格：25 mg | 目录价：￥4932 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TDZD-8
别名:
NP 01139; 2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
保存温度:
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
运输温度:
Blue Ice
产品形式:
Lyophilized
产地:
美国
生产商:
Prosci
功能与背景:
TDZD-8 is a non-ATP competitive selective inhibitor of the serine/threonine kinase glycogen synthase kinase 3β (GSK3β; IC50 = 2µM), binding to the active site of GSK3β. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, cAMP-dependent protein kinase or protein kinase C (IC50s = >100 µM), but inhibits PKC and Flt-3 activities (IC50 = 1.4-5.5µM and 673nM, respectively).
TDZD-8 has been used to study the role of GSK3β during stem cell differentiation as well as in cell and animal models of Alzheimer’s disease and other neurodegenerative disorders.
TDZD-8 is a potent anti-proliferative and pro-apoptotic agent of glioma cells in vitro and in vivo. These effects are associated with an early activation of extracellular signal-regulated kinase (ERK), which is followed by an increased expression of the early growth response-1 (EGR-1) and p21.
TDZD-8 potentially inhibits the 33.8-kDa Main protease (Mpro)/3C-like protease of SARS-CoV-2, consequently inhibiting viral transcription and replication and possibly inhibiting spread of COVID-19.
纯度:
greater than or equal to 98% (HPLC)
CAS号:
327036-89-5
分子式:
C10H10N2O2S
您可能感兴趣的产品
2-Oxoarginine
货号：9004337-1 mg
LCC-12 (formate)
货号：46743-1 mg
Guanosine 5′-diphospho-D-mannose (sodium salt)
货号：46575-10 mg
Necrocide 1
货号：46570-1 mg
2'-O-Methylpseudouridine
货号：46554-1 mg
Nampt Activator-1
货号：46510-10 mg
1-(3-Hydroxyphenyl)dihydropyrimidine-2,4(1H,3H)-dione
货号：46507-100 mg
DS-6930
货号：46506-1 mg
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询