官网链接
折扣/货期| 货号：90-549 | 规格：100 ug | 目录价：￥10986.3 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Tim-3 Recombinant Protein
别名:
TIM3, TIMD3, Hepatitis A Virus Cellular Receptor 2, HAVcr-2, T Cell Immunoglobulin and Mucin Domain-containing Protein 3
表达系统:
CHO cells
保存温度:
Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
运输温度:
Blue Ice
产品形式:
Lyophilized
存储溶液:
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μl sterile water. Add 1X PBS to the desired protein concentration.
产地:
美国
生产商:
Prosci
功能与背景:
The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.
纯度:
>98% (SDS-PAGE).
Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
生物活性:
Measured by its binding ability in a functional ELISA.
Accession #:
NP_116171
您可能感兴趣的产品
Histone H3 (human, recombinant)
货号：10263-1 mg
Influenza B Strain B/Hong Kong 5/72 Antigen
货号：11-576
TMIGD2 Recombinant Protein
货号：RF16120-01
TIM3 Recombinant Protein
货号：RF16100-01
B7-H3 Recombinant Protein
货号：RF16090-01
LAG-3 Recombinant Protein
货号：RF16080-01
B7-H5 Recombinant Protein
货号：RF16070-01
LIGHT Recombinant Protein
货号：RF16060-01
促销活动
复制QQ号成功，请打开QQ后添加好友进行咨询