Tim-4 Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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Tim-4 Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：90-552

规格：100 ug

目录价：￥10986.3

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Tim-4 Recombinant Protein

别名:

TIM4, TIMD4, T Cell Immunoglobulin and Mucin Domain-containing Protein 4

表达系统:

CHO cells

保存温度:

Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μl sterile water. Add 1X PBS to the desired protein concentration.

产地:

美国

生产商:

Prosci

功能与背景:

Mouse T cell immunoglobulin and mucin domain-containing protein 4, also known as T cell membrane protein 4, TIMD4 and TIM4 is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and TIM family. TIM4 contains one Ig-like V-type (immunoglobulin-like) domain. It is expressed on dendritic cells and macrophages. TIM4 plays an important role in the proliferation of T helper type 2 (Th2) cells. TIM4 is involved in regulating T cell proliferation and lymphotoxin signaling. It is a ligand for HAVCR1 / TIMD1. The expression of TIM4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIM4 and TIM1 are phosphatidylserine receptors for the engulfment of apoptotic cells and may also be involved in intercellular signaling in which exosomes are involved. Modulation of TIM4 production in dendritic cells (DCs) represents a novel therapeutic approach for the treatment of peanut allergy.

纯度:

≥98% (SDS-PAGE).

Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).

生物活性:

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.

Accession #:

NP_848874

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