TrkA / NTRK1 (33-417) Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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TrkA / NTRK1 (33-417) Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：11-395

规格：0.1 mg

目录价：￥9038.25

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

TrkA / NTRK1 (33-417) Recombinant Protein

别名:

TrkA,NTRK1,MTC,TRK,TRKA,Trk-A

实验应用:

表达系统:

HEK293 cells

保存温度:

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

Tris with Glycine, Arginine and NaCl, pH7.5

产地:

美国

生产商:

Prosci

功能与背景:

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

纯度:

>95% as determined by SDS-PAGE.

Accession #:

NP_001012331.1

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