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折扣/货期| 货号：CDX-U0027-M050 | 规格：50 mg | 目录价：￥2310 |
| 货号：CDX-U0027-M100 | 规格：100 mg | 目录价：￥3864 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Ulipristal acetate
别名:
(11beta)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione; CDB-2914; HRP 2000; RU 44675
产品描述:
Ulipristal acetate is a selective progesterone receptor modulator (SPRM) that binds to the human progesterone receptors PR-A and PR-B (EC50s=8.5 and 7.7nM, respectively), rabbit uterine PR (EC50=13.6nM), and rabbit thymic glucocorticoid receptor (GR; EC50=15.4nM). It is selective for human progesterone receptors over the human estrogen receptor (ER; EC50>10,000nM). It inhibits growth of IGROV-1 and SKOV3 human ovarian cancer cells (IC50s=15.5 and 31.5µM, respectively) even after resistance to combined cisplatin and paclitaxel treatment has developed. Ulipristal acetate reverses the proliferative effect of progesterone on patient-derived germline mutant BRCA1 breast tissue xenografts in ovariectomized athymic mice. Formulations containing ulipristal acetate have been used as emergency contraceptives and to treat uterine fibroids.
宿主来源:
Synthetic
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
475.62
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
126784-99-4
分子式:
C30H37NO4
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