URMC-099-其他小分子化合物-深圳欣博盛生物科技有限公司

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URMC-099

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：SYN-1211-M001	规格：1 mg	目录价：￥1512
货号：SYN-1211-M005	规格：5 mg	目录价：￥2716
货号：SYN-1211-M010	规格：10 mg	目录价：￥4228
货号：SYN-1211-M050	规格：50 mg	目录价：￥14364
货号：SYN-1211-M100	规格：100 mg	目录价：￥询价

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

URMC-099

别名:

3-(1H-Indol-5-yl)-5-(4-(4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3- b]pyridine

产品描述:

Inhibition of mixed lineage kinase 3 (MLK-3) is a potential strategy for the treatment of Parkinson's disease and HIV-1 associated neuro-cognitive disorders (HAND), requiring an inhibitor that can achieve significant brain concentration levels. URMC-099 is an orally bioavailable MLK-3 inhibitor with excellent brain exposure in mouse PK models and minimal interference with key human CYP450 enzymes or hERG channels. URMC-099 inhibits multiple kinase pathways, including MLK-3 (14nM) and leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (11nM).

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

421.5

产品形式:

solid

产地:

瑞士

纯度:

>95% (HPLC)