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折扣/货期| 货号：32-235 | 规格：0.1 mL | 目录价：￥7581.6 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Vimentin Antibody [9E7E7 / 5G3F10]
别名:
HEL113, CTRCT30
反应种属:
Human
宿主来源:
Mouse
实验应用:
ELISA
同种型:
IgG1
克隆性:
Monoclonal
克隆号:
9E7E7 / 5G3F10
偶联:
Unconjugated
产品浓度:
batch dependent
保存温度:
Vimentin monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
运输温度:
Blue Ice
存储溶液:
Ascitic fluid containing 0.03% sodium azide.
产地:
美国
生产商:
Prosci
功能与背景:
Vimentin is the major subunit protein of the intermediate filaments of mesenchymal cells. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis. Immunohistochemical staining for Vimentin is characteristic of sarcomas (of neural, muscle and fibroblast origin) compared to carcinomas which are generally negative. Melanomas, lymphomas and vascular tumors may all stain for Vimentin. Vimentin antibodies are thus of value in the differential diagnosis of undifferentiated neoplasms and malignant tumors. They are generally used with a panel of other antibodies including those recognising cytokeratins, lymphoid markers, S100, desmin and neurofilaments.
Accession #:
P08670
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