官网链接
折扣/货期| 货号：SYN-3006-M005 | 规格：5 mg | 目录价：￥602 |
| 货号：SYN-3006-M010 | 规格：10 mg | 目录价：￥756 |
| 货号：SYN-3006-M050 | 规格：50 mg | 目录价：￥1064 |
| 货号：SYN-3006-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Vorinostat
别名:
SAHA; Suberoyl anilide bishydroxamide; Suberoylanilide hydroxamic acid;
产品描述:
Vorinostat (SAHA, MK0683, Zolinza) inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50< 86 nM). These enzymes catalyze the removal of acetyl groups from the lysine residues of histones proteins. In some cancer cells, there is an overexpression of HDACs, or an aberrant recruitment of HDACs to oncogenic transcription factors causing hypoacetylation of core nucleosomal histones. By inhibiting histone deacetylase, vorinostat causes the accumulation of acetylated histones and induces cell cycle arrest and/or apoptosis of some transformed cells. The mechanism of the antineoplastic effect of vorinostat has not been fully characterized.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
264.3
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95%
CAS号:
149647-78-9
分子式:
C14H20N2O3
溶解度:
Soluble in DMSO or ethanol. Almost insoluble in water.
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