WNT-7A Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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WNT-7A Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：40-577-0.003 mg	规格：0.003 mg	目录价：￥3783
货号：40-577-0.015 mg	规格：0.015 mg	目录价：￥5674.5

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

WNT-7A Recombinant Protein

别名:

Protein Wnt-7a

表达系统:

HEK293 cells

保存温度:

The lyophilized WNT-7A recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted WNT-7A stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing WNT-7A recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

运输温度:

Blue Ice

产品形式:

Lyophilized

产地:

美国

生产商:

Prosci

功能与背景:

Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family ultimately leading to the disruption of β-Catenein degradation. Intracellular accumulation of β-Catenin increases translocation of the protein into the nucleus where it binds to TCF/LEF transcription factors and induces the expression of numerous genes. Increased Wnt/β-Catenein signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers. Recombinant human Wnt-7a is a 35.5 kDa glycoprotein containing 318 amino acids. Due to glycosylation, Wnt-7a migrates between 40-55 kDa by SDS-PAGE gel under unreduced conditions.

纯度:

Greater than 80% by SDS-PAGE gel and HPLC analyses.

生物活性:

Determined by its ability to decrease alkaline phosphatase activity in CCL-226 cells when treated with 25 ng/ml of Murine Wnt-3a.

Accession #:

NP_004616.2

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