官网链接
折扣/货期| 货号：CDX-E0533-M005 | 规格：5 mg | 目录价：￥742 |
| 货号：CDX-E0533-M025 | 规格：25 mg | 目录价：￥2212 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
别名:
10058-F4
产品描述:
c-Myc is a proto-oncogene that plays an important role in cell proliferation, differentiation, and apoptosis. 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone [10058-F4] is a cell-permeable thiazolidinone compound that specifically inhibits the c-Myc-Max interaction/dimerization at 64 µM, preventing c-Myc-dependent gene expression and cell proliferation. 10058-F4 inhibits tumor cell growth and proliferation in a c-Myc-dependent manner both in vitro and in vivo. 10058-F4 induces cell-cycle arrest (G0/G1 phase) and apoptosis. 10058-F4 has been found to also upregulate cyclin-dependent kinase (CDK) inhibitors, p21 and p27. In addition to c-Myc, 10058-F4 inhibits the nuclear Myc protein, N-Myc, at 50 µM, inducing arrest, apoptosis, and differentiation in neuroblastoma cells overexpressing the gene for N-Myc. This compound can be used to delineate novel actions of Myc proteins, especially those related to lipid and glucose metabolism. 10058-F4 downregulates human telomerase reverse transcriptase and enhances chemosensitivity in several human cancer cell lines.
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
249.35
产品形式:
solid
产地:
瑞士
纯度:
>95% (NMR)
CAS号:
403811-55-2
分子式:
C12H11NOS2
促销活动
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