官网链接
折扣/货期| 货号：SYN-1001-M001 | 规格：1 mg | 目录价：￥910 |
| 货号：SYN-1001-M005 | 规格：5 mg | 目录价：￥1358 |
| 货号：SYN-1001-M010 | 规格：10 mg | 目录价：￥2114 |
| 货号：SYN-1001-M050 | 规格：50 mg | 目录价：￥8008 |
| 货号：SYN-1001-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ABT-737
别名:
ABT737
产品描述:
ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation. ABT-737 exhibits single-agent-mechanism-based killing of cells from lymphoma and small-cell lung carcinoma lines, as well as primary patient-derived cells, and in animal models, ABT-737 improves survival, causes regression of established tumors, and produces cures in a high percentage of the mice. ABT-737 binds to Bcl-2, Bcl-xL and Bcl-w with very high affinities (Ki <1 nM) and also shows a very high specificity over Mcl-1 and A1.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
813.4
产品形式:
solid
产地:
瑞士
纯度:
>95%
CAS号:
852808-04-9
分子式:
C42H45ClN6O5S2
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