ADAM17 Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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ADAM17 Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：96-968

规格：0.05 mg

目录价：￥11969

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

ADAM17 Recombinant Protein

别名:

ADAM17,TACE,CD156b

实验应用:

表达系统:

HEK293 cells

保存温度:

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

50 mM MES, 150 mM NaCl, pH6.5

产地:

美国

生产商:

Prosci

功能与背景:

Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation.

纯度:

>90% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.

Accession #:

Q9Z0F8

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