B7-1 Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

首页产品中心其他重组蛋白

B7-1 Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：96-969

规格：0.1 mg

目录价：￥7582

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

B7-1 Recombinant Protein

别名:

CD80,B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7

实验应用:

ELISA,WB

表达系统:

HEK293 cells

保存温度:

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

PBS, pH7.4

产地:

美国

生产商:

Prosci

功能与背景:

B7-1 and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T and Bcell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B71 and B72 with a 20 100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-kappaB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

纯度:

>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.

生物活性:

Measured by its binding ability in a functional ELISA. Immobilized Mouse B7-1, His Tag at 2 ug/mL (100 uL/well) can bind Mouse CTLA-4, Fc Tag with a linear range of 0.12-0.5 ng/mL.

Accession #:

Q00609-1

您可能感兴趣的产品

Cholera Toxin B Subunit (recombinant) - Biotinylated

货号：46159

BRD9 bromodomain (human, recombinant)

货号：11509

CUTANA™ SsDddA Inhibitor Protein, SsDddI

货号：15-1038

Human Recombinant Alpha Synuclein E83Q Mutant PFFs

货号：SPR-539E

Human Recombinant Alpha Synuclein E83Q Mutant PFFs