官网链接
折扣/货期| 货号：SYN-1005-M001 | 规格：1 mg | 目录价：￥2954 |
| 货号：SYN-1005-M005 | 规格：5 mg | 目录价：￥5824 |
| 货号：SYN-1005-M010 | 规格：10 mg | 目录价：￥9142 |
| 货号：SYN-1005-M050 | 规格：50 mg | 目录价：￥询价 |
| 货号：SYN-1005-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Akt-I-1
别名:
AktI1
产品描述:
The compound (Akt-I-1) inhibits only Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of AKT1 isoform, AKT-I-1 blocked the phosphorylation and activation of AKT1 by PDK1 (phosphoinositide-dependent kinase 1). The inhibitor was found to be cell-active and to block phosphorylation of Akt at Thr308 and Ser473, reduce the levels of active Akt in cells, block the phosphorylation of known Akt substrates and promote TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand)-induced apoptosis in LNCap prostate cancer cells.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
378.5
产品形式:
solid
产地:
瑞士
纯度:
>95%
CAS号:
473382-39-7
分子式:
C22H30N6
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