官网链接
折扣/货期| 货号：SYN-1006-M001 | 规格：1 mg | 目录价：￥2954 |
| 货号：SYN-1006-M005 | 规格：5 mg | 目录价：￥5824 |
| 货号：SYN-1006-M010 | 规格：10 mg | 目录价：￥9142 |
| 货号：SYN-1006-M050 | 规格：50 mg | 目录价：￥询价 |
| 货号：SYN-1006-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Akt-I-2 hydrochloride
别名:
AktI2
产品描述:
The compound (Akt-I-2) inhibited both Akt1 and Akt2 with IC(50) values of 2.7 and 21 µM respectively. It does not inhibit AKT3. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of AKT1 and AKT2 isoforms, AKT-I-1,2 blocked the phosphorylation and activation of AKT1 and AKT2 by PDK1 (phosphoinositide-dependent kinase 1). The inhibitor was found to be cell-active and to block phosphorylation of Akt at Thr308 and Ser473, reduce the levels of active Akt in cells, block the phosphorylation of known Akt substrates and promote TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand)-induced apoptosis in LNCap prostate cancer cells.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
339.4 . 36.5
产品形式:
solid
产地:
瑞士
纯度:
>95%
CAS号:
473382-48-8
分子式:
C23H21N3 . HCl
促销活动
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