Alpha B Crystallin Antibody-多抗-深圳欣博盛生物科技有限公司

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Alpha B Crystallin Antibody

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPC-126B

规格：200 µl

目录价：￥3641.4

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Alpha B Crystallin Antibody

别名:

AACRYA Antibody, Alpha crystallin B chain Antibody, CRYA2 Antibody, CRYAB Antibody, CTPP2 Antibody, HSPB5 Antibody, NY REN 27 antigen Antibody

产品描述:

Rabbit Anti-Human alpha B Crystallin Polyclonal

反应种属:

Human | Mouse | Rat | Bovine | Chicken

宿主来源:

Rabbit

实验应用:

WB | IHC | ICC/IF

靶标/特异性:

Detects ~22kDa. Does not cross-react with αA-crystallin.

推荐稀释度:

WB (1:5000), ICC/IF (1:120); optimal dilutions for assays should be determined by the user.

免疫原:

Synthetic peptide corresponding to human alpha B crystallin conjugated to KLH

免疫原种属:

Human

克隆性:

Polyclonal

纯化方式:

Affinity Purified

偶联:

Unconjugated

产品浓度:

1 mg/ml

保存温度:

-20ºC

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases (8). Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions (9).

Accession #:

NP_001876.1