官网链接
折扣/货期| 货号：SYN-1007-M001 | 规格：1 mg | 目录价：￥2954 |
| 货号：SYN-1007-M005 | 规格：5 mg | 目录价：￥5824 |
| 货号：SYN-1007-M010 | 规格：10 mg | 目录价：￥9226 |
| 货号：SYN-1007-M050 | 规格：50 mg | 目录价：￥询价 |
| 货号：SYN-1007-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AMG-47a
别名:
AMG47a
产品描述:
The lymphocyte-specific kinase (Lck) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and natural killer (NK) cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell receptor (TCR), which leads to normal T cell development and activation. Selective inhibition of Lck is expected to offer a new therapy for the treatment of T-cell-mediated autoimmune and inflammatory disease. AMG-47 is one of two optimized chemical compounds that has been shown to be extremely effective in vivo and in vitro in inhibiting Lck as well as a number of other receptor tyrosine kinases. In an anti-CD3/ IL-2 mouse model system AMG-47 has been shown to be effective in inhibiting the Lck mediated anti-inflammatory activity (ED50 11 mg/kg; 630nM) in vivo. In multiple other in vitro assays, AMG-47 exhibits subnanomolar inhibition against Lck, and low (< 10nM) inhibition against other hard to inhibit kinases such as KDR and SRC and MAPK alpha (p38alpha). Moreover at slightly higher doses but well under 10µM, AMG-47 effectively inhibits the JNK family of kinases including TYK2 at ~ 1.2µM.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
535.6
产品形式:
solid
产地:
瑞士
纯度:
>95%
CAS号:
882663-88-9
分子式:
C29H28F3N5O2
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询