官网链接
折扣/货期| 货号：SYN-1111-M001 | 规格：1 mg | 目录价：￥2870 |
| 货号：SYN-1111-M005 | 规格：5 mg | 目录价：￥5824 |
| 货号：SYN-1111-M010 | 规格：10 mg | 目录价：￥9142 |
| 货号：SYN-1111-M050 | 规格：50 mg | 目录价：￥询价 |
| 货号：SYN-1111-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AMG-51
别名:
AMG51
产品描述:
c-Met kinase is the receptor for hepatocyte growth factor (HGFR). Primarily expressed on epithelial and mesenchymal cells its normal function is associated with wound healing, liver regeneration and embryo development. However, dysregulation of c-Met through overexpression, gene amplification, mutation or a ligand-dependent autocrine/paracrine loop is associated with tumorigenesis. c-Met dysregulation in human cancer patients is typically associated with a poor prognosis, aggressive disease, increased metastasis and shortened patient survival. Targeting the hepatocyte growth factor/c-Met signalling pathway as a means of cancer therapy has, therefore, become increasingly popular with a number of different therapeutic approaches undergoing clinical trials. AMG-51 represents a modified novel pyrimidone 7 compound that demonstates good effectiveness against c-Met with few off target effects at set concentrations. AMG-51 shows the enzyme selectivity of c-Met with a Ki of 4.9nM, with off target proteins such as IGFR with a Ki of 22nM, Ron with a Ki of 28nM, and KDR with Ki of 139nM.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
629.7
产品形式:
solid
产地:
瑞士
纯度:
>95%
CAS号:
890019-63-3
分子式:
C34H33F2N5O5
促销活动
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