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折扣/货期| 货号：SIH-605-5MG | 规格：5 mg | 目录价：￥8496 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Aphidicolin
别名:
(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol; (from Nigrospora sp.)
产品描述:
DNA polymerase inhibitor
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
338.5
产品形式:
White powder
产地:
加拿大
功能与背景:
Aphidicolin specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases (1). Arrests cell cycle at early S phase while allowing continued cell growth(2). Potentiates apoptosis induction induced by other agents(3). Increases gene amplification frequency in HeLa S3 cells overexpressing Bcl-2(4).
纯度:
>98% (TLC); NMR (Conforms)
来源:
Synthetic
CAS号:
38966-21-1
分子式:
C20H34O4
溶解度:
May be dissolved in DMSO (10 mg/ml); or ethanol (1 mg/ml)
PubChem CID:
457964
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