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折扣/货期| 货号：SYN-1010-M001 | 规格：1 mg | 目录价：￥910 |
| 货号：SYN-1010-M005 | 规格：5 mg | 目录价：￥1512 |
| 货号：SYN-1010-M010 | 规格：10 mg | 目录价：￥2268 |
| 货号：SYN-1010-M050 | 规格：50 mg | 目录价：￥8162 |
| 货号：SYN-1010-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AT7519 hydrochloride
别名:
AT-7519
产品描述:
AT7519 is a potent inhibitor of several CDK family members. AT7519 showed potent antiproliferative activity (40-940nM) in a panel of human tumor cell lines, and the mechanism of action was shown here to be consistent with the inhibition of CDK1 and CDK2 in solid tumor cell lines. AT7519 caused cell cycle arrest followed by apoptosis in human tumor cells and inhibited tumor growth in human tumor xenograft models. Tumor regression was observed following twice daily dosing of AT7519 in the HCT116 and HT29 colon cancer xenograft models. Also it has been shown that the biological effects are linked to inhibition of CDKs in vivo and that AT7519 induces tumor cell apoptosis in these xenograft models. Moreover, AT7519 has an attractive biological profile and is well tolerated and effective making it a more plausible candidate for clinical development than previously available CDK inhibitors. In in vitro kinase assays AT7519 showed nanomolar levels of activity from < 10 to 2400 for cyclins; only one other non-cyclin related kinase was inhibited at levels below 10µM (GSK3beta, 89nM), all others tested had IC(50)'s of greater than 10,000nM.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
382.2 . 36.5
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95%
CAS号:
902135-91-5
分子式:
C16H17Cl2N5O2 . HCl
溶解度:
Soluble in DMSO or ethanol.
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