AZ 960-其他小分子化合物-深圳欣博盛生物科技有限公司

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AZ 960

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3752-M001	规格：1 mg	目录价：￥960
货号：AG-CR1-3752-M005	规格：5 mg	目录价：￥1980
货号：AG-CR1-3752-M025	规格：25 mg	目录价：￥5400

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

AZ 960

别名:

AZ960

产品描述:

AZ-960 is a potent, selective and ATP-competitive JAK2 inhibitor that inhibits JAK2 kinase with a Ki of 0.45nM in vitro (3-fold selective over JAK3) and induces growth arrest and apoptosis in adult T cell leukemia (ATL) cells. Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2, where a switch from valine to phenylalanine occurs at position 617 (V617F). Furthermore, constitutive activation of the JAK2 signaling pathway is associated with aggressive adult T cell leukemia/lymphoma. AZ-960 induces growth arrest and apoptosis of human T cell lymphotropic virus type 1, HTLV-1-infected T cells (MT-1 and MT-2) in parallel with downregulation of the phosphorylated forms of JAK2 and Bcl-2 family proteins including Bcl-2 and Mcl-1. It can decrease STAT3/5 phosphorylation and inhibit cell proliferation in a SET-2 human megakaryoblastic cell line that is heterozygous for the JAK2 V617F mutation with a GI50 value of 33 nM. AZ-960 shows anti-parasitic activity through selective inhibition of the Trypanosoma brucei ERK8 inhibitor (TbERK8).

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

354.4

产品形式:

solid

产地:

瑞士

纯度:

>95%