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折扣/货期| 货号：AG-CR1-3752-M001 | 规格：1 mg | 目录价：￥840 |
| 货号：AG-CR1-3752-M005 | 规格：5 mg | 目录价：￥2520 |
| 货号：AG-CR1-3752-M025 | 规格：25 mg | 目录价：￥8820 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AZ 960
别名:
AZ960
产品描述:
AZ-960 is a potent, selective and ATP-competitive JAK2 inhibitor that inhibits JAK2 kinase with a Ki of 0.45nM in vitro (3-fold selective over JAK3) and induces growth arrest and apoptosis in adult T cell leukemia (ATL) cells. Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2, where a switch from valine to phenylalanine occurs at position 617 (V617F). Furthermore, constitutive activation of the JAK2 signaling pathway is associated with aggressive adult T cell leukemia/lymphoma. AZ-960 induces growth arrest and apoptosis of human T cell lymphotropic virus type 1, HTLV-1-infected T cells (MT-1 and MT-2) in parallel with downregulation of the phosphorylated forms of JAK2 and Bcl-2 family proteins including Bcl-2 and Mcl-1. It can decrease STAT3/5 phosphorylation and inhibit cell proliferation in a SET-2 human megakaryoblastic cell line that is heterozygous for the JAK2 V617F mutation with a GI50 value of 33 nM. AZ-960 shows anti-parasitic activity through selective inhibition of the Trypanosoma brucei ERK8 inhibitor (TbERK8).
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
354.4
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95%
CAS号:
905586-69-8
分子式:
C18H16F2N6
溶解度:
Soluble in DMSO (20mg/ml), DMF (20mg/ml) or ethanol (2mg/ml).
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