Budesonide-其他小分子化合物-深圳欣博盛生物科技有限公司

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Budesonide

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3753-M010	规格：10 mg	目录价：￥询价
货号：AG-CR1-3753-M050	规格：50 mg	目录价：￥询价
货号：AG-CR1-3753-M250	规格：250 mg	目录价：￥询价

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Budesonide

别名:

16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione

产品描述:

Budesonide is a glucocorticoid and an agonist of glucocorticoid receptors (EC50=45.7pM in a transactivation assay), selective for glucocorticoid over mineralocorticoid receptors. Budesonide is a synthetic anti-inflammatory agent that displays chemopreventive activity. It is used as an anti-inflammatory agent in the treatment of asthma, rhinitis and inflammatory bowel disease and is evaluated in prevention of lung cancer. It prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. It also reverses DNA hypomethylation and modulates expression of cancer related genes. Due to its potent activity, as an inhaled glucocorticoid, in reducing airway inflammation, Budesonide has potential as treatment for early COVID-19 infection. In vitro studies have shown that inhaled glucocorticoids can reduce the replication of SARS-CoV-2 in airway epithelial cells and downregulate the expression of ACE2 and TMPRSS2 genes, which are critical for viral cell entry. Budesonide in combination with glycopyrronium and formoterol has been shown to inhibit viral replication of the coronavirus HCoV-229E, by inhibiting receptor expression and/or endosomal function.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

430.5

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)