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折扣/货期| 货号：AG-CR1-3657-M001 | 规格：1 mg | 目录价：￥360 |
| 货号：AG-CR1-3657-M005 | 规格：5 mg | 目录价：￥960 |
| 货号：AG-CR1-3657-M025 | 规格：25 mg | 目录价：￥2280 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
AZ191
别名:
N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
产品描述:
Cell permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50=17nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. Used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle progression. Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) belongs to a family of nuclear-localized protein kinases and participates in the regulation of the cell cycle with key roles in proliferation and differentiation. It is upregulated in solid tumors and gain-of-function mutations in the gene encoding this kinase have been linked to metabolic syndrome.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
429.5
产品形式:
solid
产地:
瑞士
纯度:
>98%
CAS号:
1594092-37-1
分子式:
C24H27N7O
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