AZ191-其他小分子化合物-深圳欣博盛生物科技有限公司

首页产品中心其他小分子化合物

AZ191

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3657-M001	规格：1 mg	目录价：￥360
货号：AG-CR1-3657-M005	规格：5 mg	目录价：￥960
货号：AG-CR1-3657-M025	规格：25 mg	目录价：￥2280

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

AZ191

别名:

N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine

产品描述:

Cell permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50=17nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. Used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle progression. Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) belongs to a family of nuclear-localized protein kinases and participates in the regulation of the cell cycle with key roles in proliferation and differentiation. It is upregulated in solid tumors and gain-of-function mutations in the gene encoding this kinase have been linked to metabolic syndrome.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

429.5

产品形式:

solid

产地:

瑞士

纯度:

>98%