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折扣/货期| 货号：AG-CR1-3658-M001 | 规格：1 mg | 目录价：￥360 |
| 货号：AG-CR1-3658-M005 | 规格：5 mg | 目录价：￥1140 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
SB415286
别名:
3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
产品描述:
Potent and selective cell permeable, ATP-competitive inhibitor of GSK3alpha with an IC50 value of 78nM (and similar potency for GSK3beta). DYRK1A inhibitor (IC50=0.9µM). Stimulates glycogen synthesis in liver cells and induces beta-catenin-dependent gene transcription. Acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. Anticancer agent with antiproliferative activity. Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis and inflammation.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
359.7
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>97%
CAS号:
264218-23-7
分子式:
C16H10ClN3O5
溶解度:
Soluble in DMSO (10mg/ml), ethanol (5mg/ml) or methanol.
促销活动
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