Bafilomycin A1 (high purity)-其他小分子化合物-深圳欣博盛生物科技有限公司

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Bafilomycin A1 (high purity)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CN2-2001-C100	规格：100 ug	目录价：￥1080
货号：AG-CN2-2001-M001	规格：1 mg	目录价：￥2040
货号：AG-CN2-2001-M005	规格：5 mg	目录价：￥8160

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Bafilomycin A1 (high purity)

别名:

NSC381866; BafA1

产品描述:

Bafilomycin A1, a macrolide antibiotic, is a highly potent, selective inhibitor of vacuolar H+-ATPases. Bafilomycin A1 is a potent inhibitor of cellular autophagy either by blocking autophagosome-lysosome fusion or by blocking lysosomal degradation. Bafilomycin A1 has several other biological properties. It induces apoptosis or acts as an ionophore, meaning it can transfer K+ ions across biological membranes. Bafilomycin A1 can induce mitochondrial swelling in the presence of K+ ions, stimulate the oxidation of pyrimidine nucleotides and uncouple oxidative phosphorylation. Inhibition of V-ATPase activity with bafilomycin A1 led to the exacerbation of NLRP3 inflammasome activation in human monocytes in response to LPS. Bafilomycin A1 also significantly inhibited SARS-CoV-2 replication. In cancer, bafilomycin A1 has been shown to inhibit the growth of tumor cells by blocking the acidification of lysosomes. In lysosomal storage disorders, bafilomycin A1 has been shown to promote the clearance of accumulated cellular waste from lysosomes. In neurodegenerative diseases, bafilomycin A1 has been shown to protect neurons from damage.

宿主来源:

Isolated from Streptomyces griseus.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

622.8

产品形式:

solid

产地:

瑞士