Manumycin A-其他小分子化合物-深圳欣博盛生物科技有限公司

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Manumycin A

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CN2-2000-M001	规格：1 mg	目录价：￥1320
货号：AG-CN2-2000-M005	规格：5 mg	目录价：￥5040
货号：AG-CN2-2000-M010	规格：10 mg	目录价：￥9240

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Manumycin A

产品描述:

Antibiotic. Apoptosis and endoplasmic reticulum stress-mediated cell death inducer. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM). Does not affect geranylgeranyltransferase (IC50 = 180 µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19 µM). Targets protein phosphatase 1alpha (PP1alpha) and reduces hydrogen peroxide. Corrects aberrant splicing of the muscle chloride channel Clcn1 in myotonic dystrophy type 1 (DM1). Shows potential anti-inflammatory activity. Irreversible human thioredoxin reductase 1 (TrxR-1) inhibitor (IC50=272nM) and inducer of NADPH oxidase activity. Acts very likely as a Michael acceptor to the nucleophilic Sec residue in the C-terminal redox center of TrxR-1 which yields a SecTRAP (selenium compromised thioredoxin reductase-derived apoptotic proteins), which promotes both apoptosis and necrosis via oxidative stress and increased intracellular reactive oxygen species (ROS) production. Due to the involvement of Ras during exosomes release, manumycin A has been investigated as an inhibitor of exosomes secretion. Acts against myotonic dystrophy type 1 (DM1). Mediates lymphoma apoptosis by targeting protein phosphatase 1alpha.

保存温度:

+20°C

运输温度:

Ambient

预期分子量:

550.6

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)