Calreticulin Antibody: Biotin-多抗-深圳欣博盛生物科技有限公司

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Calreticulin Antibody: Biotin

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPC-122B-BI

规格：200 µl

目录价：￥4662

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Calreticulin Antibody: Biotin

别名:

CALR Antibody, Calregulin Antibody, cC1qR Antibody, CRP55 Antibody, ERp60 Antibody, HSCBP Antibody, RO Antibody, SSA Antibody, grp60 Antibody

产品描述:

Rabbit Anti-Human Calreticulin Polyclonal

反应种属:

宿主来源:

Rabbit

实验应用:

WB | IHC | ICC/IF | IP | FCM

靶标/特异性:

Detects ~63kDa.

推荐稀释度:

WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

免疫原:

Human calreticulin synthetic peptide with a cysteine residue added and the peptide conjugated to KLH

免疫原种属:

Human

克隆性:

Polyclonal

纯化方式:

Peptide Affinity Purified

偶联:

Biotin

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

Calreticulin is a multifunctional, highly conserved Ca2+ -binding protein that is localized to the endoplasmic reticulum (ER), but has also been detected in the nucleus and nuclear envelop. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus (1-3). CRT's three domains include a 180 residue N-terminal domain, a proline-rich P-domain (residues 189-288) that binds Ca2+ with high affinity and shares homology with calnexin (CNX) and calmegin, and a 110 residue C-terminal domain that binds Ca2+ with low affinity but high capacity (1,3). Recent studies suggest that this soluble ER protein has a multifunctional role. It appears to be involved in calcium storage and regulation as well as having a molecular chaperone activity. It has been shown to interact with the cytoskeleton and to be involved in the regulation of gene expression. Calreticulin may also play a role in cellular proliferation including its apparent activity in the proliferation of certain viruses within mammalian host cells (4, 5), and it has also been shown to be induced in response to various types of cell stress including amino acid deprivation (6). Close interconnections among protein synthesis, gene expression and calcium signaling have been observed by many researchers in recent years. Calreticulin might be centrally located and therefore it crucially participates in the coordination of many functions by the cell (4, 5). Studies also suggest its involvement in a few diseases such as systemic lupus erythematosus, rheumatoid arthritis, celiac disease, complete congenital heart block, and halothane hepatitis (1).

Accession #:

NP_004334.1