CD40 Ligand Recombinant Protein (Animal Free)-其他重组蛋白-深圳欣博盛生物科技有限公司

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CD40 Ligand Recombinant Protein (Animal Free)

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：40-759

规格：10 ug

目录价：￥4071.6

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

CD40 Ligand Recombinant Protein (Animal Free)

别名:

soluble CD40 Ligand, TNFSF5, TRAP, CD154, Gp39, T-BAM

表达系统:

E. coli

保存温度:

The recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing the recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

运输温度:

Blue Ice

产品形式:

Lyophilized

产地:

美国

生产商:

Prosci

功能与背景:

CD40, a member of the TNF receptor superfamily, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40 Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to “immunodeficiency with hyper-IgM”, a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant Human soluble CD40 ligand is a 16.3 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.

纯度:

≥ 98% by SDS-PAGE gel and HPLC analyses.

生物活性:

Determined by its ability to stimulate the proliferation of HEK-Blue™ CD40 reporter cells.

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