sRank Ligand Recombinant Protein (Animal Free)-其他重组蛋白-深圳欣博盛生物科技有限公司

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sRank Ligand Recombinant Protein (Animal Free)

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：40-758

规格：2 ug

目录价：￥4071.6

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

sRank Ligand Recombinant Protein (Animal Free)

别名:

soluble Receptor Activator of NF-κB Ligand, TNFSF11, TRANCE (TNF-related activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor)

表达系统:

E. coli

保存温度:

The recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing the recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

运输温度:

Blue Ice

产品形式:

Lyophilized

产地:

美国

生产商:

Prosci

功能与背景:

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK+ T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Human RANKL is reactive on murine cells. Recombinant Human sRANKL is a 20.0 kDa polypeptide comprising the TNF-homologous region of RANKL (176 amino acid residues).

纯度:

≥ 98% by SDS-PAGE gel and HPLC analyses.

生物活性:

Determined by its dose-dependent ability to induce reporter gene in HT-29 NF-κB Luc reporter cells.

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