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折扣/货期| 货号：AG-CN2-0410-M100 | 规格：100 mg | 目录价：￥240 |
| 货号：AG-CN2-0410-M500 | 规格：500 mg | 目录价：￥720 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Chenodeoxycholic acid
别名:
CDCA; Ulmenide; Kebilis; Hekbilin; Fluibil; Chenodiol; Anthropodeoxycholic acid
产品描述:
Cytotoxic hydrophobic primary bile acid [1]. Activator of farnesoid X receptor (FXR), a nuclear receptor that is hepatoprotective and regulates bile acid synthesis (cholesterol 7alpha-hydroxylase (CYP7A1) suppression), conjugation and transport, as well as genes involved in lipid and glucose metabolism and [4-6, 14]. Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, insulin resistance, hyperlipidemia and atherosclerosis [1, 8, 9, 12]. Inhibitor of 5beta-reductase (AKR1D1) [10, 15]. Potent selective inhibitor of DD2 (AKR1C2) [3]. Potent inhibitor of 11beta-HSD1 dehydrogenase [7]. Changes tumor cell viability via IL-6 pathway [11]. Anticancer compound. Apoptosis inducer [13]. Immunosuppressive and anti-inflammatory compound. Modulates oxidative stress [2, 16]. Differentiation regulator of mouse embryonic stem cells [17]. Used for dissolution of cholesterol gallstones.
宿主来源:
Synthetic. Originally isolated from bile.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
392.6
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95% (NMR)
CAS号:
474-25-9
分子式:
C24H40O4
溶解度:
Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water.
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