Curcumin (high purity) Sterile Solution-其他小分子化合物-深圳欣博盛生物科技有限公司

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Curcumin (high purity) Sterile Solution

品牌：Adipogen

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说明书

折扣/货期

货号：IAX-700-101-L001

规格：1 ml

目录价：￥3192

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Curcumin (high purity) Sterile Solution

别名:

Curcumin (high purity) Lipodisq Sterile Solution; BRN 2306965; CCRIS 3257; NSC 32982; NSC 687842; CI 75300; 1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione, diferuloylmethane, nano-Curcumin in a detergent-free nano-formulation made of styrene-maleic acid lipid particles (SMALP)

产品描述:

Curcumin (high purity) Lipodisq Sterile Solution is a ready-to-use nano-formulated aqueous solution. Curcumin is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with anti-oxidant, anti-inflammatory, anti-cancer, anti-viral and anti-bacterial activities [1-20]. However, curcumin shows poor absorption, biodistribution, metabolism and bioavailability. To increase the bioavailability, enhance circulation, improve permeability and resistance to metabolic processing several formulations of curcumin have been prepared which include nanoparticles, liposomes, micelles and phospholipid complexes [21-25]. Curcumin (high purity) Lipodisq is based on a nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilized by a chaperone molecule annulus. Internal properties of the phospholipid membrane support the disposition and stabilization of drug molecule candidates and preserve the native conformation of membrane molecules. The resulting encapsulated actives are rendered water-soluble and specialized for intra-cellular penetration/delivery via endosomal uptake mechanisms. Lipodisq solutions show a good safety profile and are suitable for in vitro and in vivo investigations.

产品浓度:

1mg/ml (0.1% w/vol) Curcumin in Lipodisq corresponds to 271.7uM solution.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

368.4

产品形式:

liquid

存储溶液:

Liquid, detergent-free discoidal nano-formulation made of styrene-maleic acid lipid particles (SMALP), lecithin and sterile water.

产地:

瑞士

纯度:

>95% (HPLC)

生物活性:

Discoidal nano-particles can incorporate hydrophobic, poorly water-soluble compounds, such as lipids, lipoproteins and glycolipids. - Cell culture tested (human macrophage cell line) (MTT). - Recommended starting dilution: 1:200 or higher. - Optimal working concentrations depend on the applications and need to be determined. - Published procedures using Lipodisq formulations (Curcumin and IAXO TLR4 antagonists) in vivo rodent models at 3-10mg/kg. Recommended route of administration is subcutaneous (s.c.) with oral or nasal application as a possible alternative, which needs to be optimized.

分子式:

C21H20O6

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