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折扣/货期| 货号：AG-CN2-0079-5100 | 规格：5 x 100 mg | 目录价：￥1800 |
| 货号：AG-CN2-0079-G001 | 规格：1 g | 目录价：￥2040 |
| 货号：AG-CN2-0079-M100 | 规格：100 mg | 目录价：￥600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Cyclosporin A
别名:
Antibiotic S 7481F1; Ciclosporin A; CsA; Cyclosporine; NSC 290193; Ramihyphin A
产品描述:
Potent immunosuppressant (same as FK-506 (Prod. No. AG-CN2-0047) and rapamycin (Prod. No. AG-CN2-0025)). Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B; calcineurin). Prevents the dephosphorylation of nuclear factor of activated T cells (NFAT) transcription factor, leading to disruption of T cell activation. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2). Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis). Antibacterial. Antifungal. Antiparasitic. Apoptosis inhibitor. Inhibits the mitochondrial permeability transition pore (MPTP) from opening, thus inhibiting cytochrome c release. NF-kappaB suppressor by induction of unfolded protein response (UPR). Anti-cancer compound. Apoptosis and autophagy inducer. Inhibits nitric oxide synthesis induced by interleukin-1alpha, lipopolysaccharides and TNF-alpha. Potently induces highly cardiogenic progenitors from embryonic stem (ES) cells.
宿主来源:
Isolated from Tolypocladium inflatum.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
1202.6
产品形式:
solid
有效期:
Stable for at least 3 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98%
CAS号:
59865-13-3
分子式:
C62H111N11O12
溶解度:
Soluble in DMSO, ethanol, methanol, dichlormethane, chloroform or acetone. Insoluble in water.
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