ENaC alpha Antibody: ATTO 390-多抗-深圳欣博盛生物科技有限公司

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ENaC alpha Antibody: ATTO 390

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPC-403D-A390

规格：100 µg

目录价：￥5077.8

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

ENaC alpha Antibody: ATTO 390

别名:

SCNN1A Antibody, Epithelial Sodium Channel-α Antibody, Epithelial Sodium Channel alpha Antibody, Alpha ENaC 2 Antibody, Alpha ENaC Antibody, Alpha NaCH Antibody, Alpha-ENaC Antibody, Amiloride sensitive epithelial sodium channel alpha subunit Antibody, Amiloride sensitive sodium channel subunit alpha Antibody, Amiloride-sensitive sodium channel subunit alpha Antibody, ENaCa Antibody, ENaCalpha Antibody, Epithelial Na(+) channel subunit alpha Antibody, Epithelial Na+ channel subunit alpha Antibody, FLJ21883 Antibody, Nonvoltage gated sodium channel 1 subunit alpha Antibody, Nonvoltage-gated sodium channel 1 subunit alpha Antibody, SCNEA Antibody, SCNN 1 Antibody, SCNN1 Antibody, SCNN1A Antibody, SCNNA_HUMAN Antibody, Sodium channel nonvoltage gated 1 alpha Antibody

产品描述:

Rabbit Anti-Rat ENaC alpha Polyclonal

反应种属:

Human | Rat | Mouse | African clawed frog (Xenopus laevis)

宿主来源:

Rabbit

实验应用:

WB | IHC | ICC/IF | IP

靶标/特异性:

Detects ~85kDa.

推荐稀释度:

WB (1:1000), ICC/IF (1:400); IHC (1:25); optimal dilutions for assays should be determined by the user.

免疫原:

Produced against a synthetic peptide mapping to the N-terminal of the alpha subunit (amino acids 46-68) of rat Alpha ENaC (antibody designation 3560-2).

免疫原种属:

Rat

克隆性:

Polyclonal

纯化方式:

Protein A Purified

偶联:

ATTO 390

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2). ENaCs are composed of three structurally related subunits that form a tetrameric channel, α, β, and γ. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).

Accession #:

NP_113736