Everolimus-其他小分子化合物-深圳欣博盛生物科技有限公司

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Everolimus

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CN2-0520-M001	规格：1 mg	目录价：￥360
货号：AG-CN2-0520-M005	规格：5 mg	目录价：￥600
货号：AG-CN2-0520-M025	规格：25 mg	目录价：￥1320

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Everolimus

别名:

42-O-(2-Hydroxyethyl)rapamycin; NVP-RAD001; RAD001; SDZRAD; Zortress; Afinitor; Certican; Votubia

产品描述:

Macrolide antibiotic, inhibiting bacterial protein synthesis. Orally available rapamycin derivative that shows improved pharmacokinetics and pharmacodynamics. Potent immunosuppressant. Binds with high affinity to the FK506 binding protein-12 (FKBP12) to generate an immunosuppressive complex that inhibits the activation of the mammalian target of rapamycin (mTOR). More selective for the mTORC1 protein complex, with little impact on the mTORC2 complex, compared to rapamycin. Since mTORC2 is believed to play an important role in glucose metabolism and the immune system, selective inhibition of mTORC1 achieves many of the benefits of rapamycin without the associated glucose intolerance and immunosuppression Anticancer agent. Inhibition of mTOR reduces the activity of effectors downstream, which leads to a blockage in the progression of cells from G1 into S phase, and subsequently inducing cell growth arrest, apoptosis and autophagy, resulting in reduction of cell proliferation, angiogenesis and glucose uptake. Inhibits tumor proliferation in vitro and in vivo. Used as an immunosuppressant to prevent rejection of organ transplants and in the treatment of renal cell cancer and other tumors.

宿主来源:

Isolated from Streptomyces hygroscopicus.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

958.2

产品形式:

solid

产地:

瑞士