FK-506 [Tacrolimus]-其他小分子化合物-深圳欣博盛生物科技有限公司

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FK-506 [Tacrolimus]

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CN2-0047-M001	规格：1 mg	目录价：￥180
货号：AG-CN2-0047-M005	规格：5 mg	目录价：￥300
货号：AG-CN2-0047-M025	规格：25 mg	目录价：￥720

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

FK-506 [Tacrolimus]

别名:

Tacrolimus; Fujimycin

产品描述:

Potent immunosuppressant (as cyclosporin A and rapamycin) [1-3]. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2) [2, 4]. Forms a complex with FK-506 binding protein 12 (FKBP12). Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B; calcineurin), leading to disruption of T cell activation [2, 4, 6, 7]. Prevents rejection of transplanted organs [3]. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis) [5, 9]. Neuroprotective. Regulates nitric oxide neurotoxicity. Neurotransmitter. Ca2+ release compound [8]. NF-kappaB suppressor by induction of unfolded protein response (UPR) [11]. Anti-cancer compound. Apoptosis inducer [10, 12].

宿主来源:

Isolated from Streptomyces tsukubaensis.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

804.0 . 18.0

产品形式:

solid

产地:

瑞士