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折扣/货期| 货号：AG-CN2-0050-M050 | 规格：50 mg | 目录价：￥300 |
| 货号：AG-CN2-0050-M250 | 规格：250 mg | 目录价：￥1140 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Orlistat
别名:
Tetrahydrolipstatin; Xenical; Alli; Ro-18-0647
产品描述:
Hypolipemic cell permeable and irreversible pancreatic, gastric and carboxylester lipase inhibitor [1-3]. Anti-obesity and antihypercholesterolemic compound [2, 5, 11]. Antitumor compound by inhibition of the thioesterase domain of fatty acid synthase (FASN) [4, 6, 9, 10]. Anti-proliferative [4, 6, 9, 10]. Causes cell cycle arrest at G1 phase. Apoptosis inducer through caspase-3 activation [6, 10]. Sn-1-selective-diacylglycerol lipases alpha (DAGLalpha) inhibitor. Targets serine hydrolases in the nervous system, such as diacylglycerol lipase (DAGL), which is responsible for the conversion of DAG to 2-AG [7]. Partially inhibits the hydrolysis of triglycerides and lowers the absorption of dietary fat, promoting weight loss [8]. Promotes the sensitivity to TRAIL in cancer cells by ROS-mediated pathways [11].
宿主来源:
Synthetic. Originally isolated from Streptomyces sp.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
495.7
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
Soluble in DMSO, ethanol or DMF.
纯度:
>98% (NMR)
CAS号:
96829-58-2
分子式:
C29H53NO5
溶解度:
Soluble in DMSO, ethanol or DMF.
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