FKBP52 Antibody: RPE-单抗-深圳欣博盛生物科技有限公司

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FKBP52 Antibody: RPE

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SMC-139D-RPE

规格：100 µg

目录价：￥5077.8

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

FKBP52 Antibody: RPE

别名:

FK506 binding protein 4 Antibody, FKBP4 Antibody, FKBP59 Antibody, HBI Antibody, HSP56 Antibody, p52 Antibody, p59 Antibody, PPIase Antibody, Rotamase Antibody, T cell FK506 binding protein Antibody

产品描述:

Mouse Anti-Human FKBP52 Monoclonal IgG2a

反应种属:

Human | Mouse | Rat | Dog | Hamster

宿主来源:

Mouse

实验应用:

WB | IHC | ICC/IF | IP

靶标/特异性:

Detects ~52kDa. Heavy chain migrates close to FKBP52 on SDS PAGE.

同种型:

IgG2a

推荐稀释度:

WB (1:2000), IHC (1:250), ICC/IF (1:1000), IP (5µg); optimal dilutions for assays should be determined by the user.

免疫原:

Synthetic peptide corresponding to the residues of human FKBP52

免疫原种属:

Human

克隆性:

Monoclonal

克隆号:

Hi52C

纯化方式:

Protein G Purified

偶联:

RPE

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

HSP90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of HSP90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an HSP90 binding site. Among the TPR cochaperones of HSP90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the HSP90 (4). Although FKBP52 and FKBP51 share ~75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different HSP90-binding characteristics (3). FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids (5).

Accession #:

NP_002005.1