FOLR1 Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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FOLR1 Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：96-995

规格：0.1 mg

目录价：￥9477

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

FOLR1 Recombinant Protein

别名:

FOLR-1,FBP,FOLR

实验应用:

ELISA,WB

表达系统:

HEK293 cells

保存温度:

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

PBS, pH7.4

产地:

美国

生产商:

Prosci

功能与背景:

Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.

纯度:

>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.

生物活性:

Measured by its binding ability in a functional ELISA. Immobilized Folic acid-BSA conjugate at 20 ug/mL (100 uL/well) can bind Mouse FOLR1, His Tag with a linear range of 0.078-1.25 ug/mL.

Accession #:

P35846-1

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