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折扣/货期| 货号：SIH-561-25MG | 规格：25 mg | 目录价：￥2390.4 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
FPS-ZM1
别名:
4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide
产品描述:
RAGE antagonist
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
327.1
产品形式:
White powder
产地:
加拿大
功能与背景:
A high-affinity RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo (1,2). In a rat model of intracerebral hemorrhage, FPS-ZM1 attenuates blood-brain barrier and white matter fiber damage (3). It ameliorates inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling (4). Attenuates AGE-induced neuroinflammation and oxidative stress in rat microglia (5). BBB permeable.
纯度:
>98% (TLC); NMR (Conforms)
来源:
Synthetic
CAS号:
945714-67-0
分子式:
C20H22ClNO
溶解度:
May be dissolved in DMSO (30 mg/ml); or Ethanol (25 mg/ml)
PubChem CID:
24752728
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