| 货号:33-585 | 规格:100 ug | 目录价:¥10986.3 |
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
Gamma Catenin Antibody [11E4.]
别名:
Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP, CTNNG, DP3
反应种属:
Human,Mouse
宿主来源:
Mouse
实验应用:
IF,WB,IP
同种型:
IgG1, kappa
克隆性:
Monoclonal
克隆号:
11E4.
纯化方式:
Protein G affinity chromatography
偶联:
Unconjugated
产品浓度:
0.2 mg/mL
保存温度:
Aliquot and Store at 2-8˚C. Avoid freez-thaw cycles.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
产地:
美国
生产商:
Prosci
功能与背景:
It recognizes a protein of 80-87kDa, identified as gamma-Catenin or Plakoglobin. The catenins (alpha, beta, gamma and δ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.
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