官网链接
折扣/货期| 货号：SYN-1126-M001 | 规格：1 mg | 目录价：￥2198 |
| 货号：SYN-1126-M005 | 规格：5 mg | 目录价：￥3332 |
| 货号：SYN-1126-M010 | 规格：10 mg | 目录价：￥5292 |
| 货号：SYN-1126-M050 | 规格：50 mg | 目录价：￥15876 |
| 货号：SYN-1126-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
GSK2126458
别名:
HYR-582
产品描述:
GSK2126458 is an orally available selective inhibitor of the class I phosphoinositide 3-kinase (PI3K) enzymesand MTOR1/2 complexes. GSK2126458 can inhibit PI3K-alpha (p85alpha/p110alpha) with IC(50) of 0.04nM. GSK2126458 has Ki values in the picomolar range for each of the class I PI3K isoforms and MTOR1/2 complexes. GSK2126458 has potent in vitro and in vivo growth-inhibitory effects on cancer cells. In comparison with other clinical PI3K inhibitors, GSK2126458 is around 100-fold more potent than BEZ235 (6nM). GSK2126458 also a low picomolar inhibitor of the common activating mutants of p110R ( E542K, E545K, and H1047R ) with Ki of 0.008nM, 0.008nM and 0.009nM in human cancer. In mechanistic cellular assays, GSK2126458 caused a significant reduction in the levels of pAKT-S473 with remarkable potency. Consistent with its activity against both PI3K R and mTOR, GSK2126458 also inhibits phosphorylation of AKT-T308 and p70S6K at low nanomolar concentrations. GSK2126458 induces a G1 cell cycle arrest and inhibits cell proliferation in a large panel of cell lines, including T47D and BT474 breast cancer lines.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
505.5
产品形式:
solid
产地:
瑞士
纯度:
>95%
CAS号:
1086062-66-9
分子式:
C25H17F2N5O3S
您可能感兴趣的产品
TBS Stock Solution (10X, pH 7.4)
货号：600232
Sodium Acetate Stock Solution (3 M, pH 5.2)
货号：600228
Saline Sodium Citrate Stock Solution (10X, pH 7.0)
货号：600224
PBS Stock Solution (10X, pH 7.4 at 1X)
货号：600221
Glycerol Stock Solution (20% v/v)
货号：600218
Triton™ X-100 Stock Solution (20% v/v)
货号：600217
Sodium Dodecyl Sulfate 10% (w/v) Stock Solution
货号：600216
EDTA Stock Solution (500 mM, pH 8.0)
货号：600215
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询