HSP40, Hdj1 Antibody: RPE-单抗-深圳欣博盛生物科技有限公司

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HSP40, Hdj1 Antibody: RPE

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SMC-145D-RPE

规格：100 µg

目录价：￥4422.6

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

HSP40, Hdj1 Antibody: RPE

别名:

DNAJ1 Antibody, NDAJB1 Antibody, HDJ1 Antibody, HSP40 Antibody, HSPF1 Antibody, DnaJ homolog subfamily B member 1 Antibody, Dna J protein homolog 1 Antibody, Heat shock 40 kDa protein 1 Antibody, HSP40 Antibody, heat shock protein 40 Antibody, Human DnaJ protein 1 Antibody, hDj-1 Antibody

产品描述:

Mouse Anti-Human HSP40, Hdj1 Monoclonal IgG1

反应种属:

Human | Mouse | Rat

宿主来源:

Mouse

实验应用:

WB | IHC | ICC/IF | IP | ELISA

靶标/特异性:

Detects ~40kDa. Does not cross-react with HDJ2 or YDJ1.

同种型:

IgG1

推荐稀释度:

WB (1:2000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

免疫原:

Recombinant Human Protein HSP40 (Hdj1)

免疫原种属:

Human

克隆性:

Monoclonal

克隆号:

3B9.E6

纯化方式:

Protein G Purified

偶联:

RPE

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS pH7.2, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

Human HSP40/DnaJ proteins comprise a large protein family, members of which feature the J domain (named after the bacterial DnaJ protein) (1). The J-domain spans the first 75 N-terminal amino acids and is separated from the C-terminal by a glycine/phenylalanine-rich domain (2). Members of the HSP40/DnaJ family play diverse roles in many cellular processes, such as folding, translocation, degradation and assembly of multi-protein complexes. In particular, Hdj1, the first human HSP40/DnaJ protein identified, plays an important role in protein translation and folding, as well as in the regulation of HSP70 function (3). HSP40 stimulates the ATPase activity of HSP70 which in turn causes conformational changes of the unfolded proteins (4, 5). The HSP40-HSP70-unfolded protein complex further binds to co-chaperones Hip, Hop and HSP90 which leads to protein folding, or components of protein degradation machinery CHIP and BAG-1 (6). Some studies have shown that the difference between HDJ1 and type 1 DNAJ proteins including HDJ2 and yeast YdjI is the result of the possession of a zinc finger domain by the latter, which helps in the function of protein folding. (7, 8).

Accession #:

NP_006136.1