Human Recombinant Rab5 Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant Rab5 Protein

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-121B

规格：100 µg

目录价：￥11138.4

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Recombinant Rab5 Protein

别名:

Rab 5A Protein, RAS associated protein RAB5A Protein, Ras related protein Rab 5 A Protein

产品描述:

Human Recombinant Rab5 Protein

反应种属:

Human

实验应用:

WB | SDS-PAGE

纯化方式:

Affinity Purified

偶联:

His tag

产品浓度:

Lot/batch specific. See included datasheet.

表达系统:

E. coli

保存温度:

-20ºC

运输温度:

Blue Ice or 4ºC

预期分子量:

~26 kDa

存储溶液:

20mM Tris/HCl, pH7.5, 0.15M NaCl

产地:

加拿大

功能与背景:

Rab5 is a 24kDa member of the Rab family of small guanosine triphosphatases (GTPases), Ras superfamily. Rab GTPases are central regulators of membrane trafficking in the eukaryotic cell. Their regulatory capacity depends on their ability to cycle between the GDP -bound inactive and GTP-bound active states. This conversion is regulated by GDP/GTP exchange factors (GEPs), GDP dissociation inhibitors (GDIs) and GTPase-activating proteins (GAPs) (1, 2). Activation of a Rab protein is coupled to its association with intracellular membranes, allowing it to recruit downstream effector proteins to the cytoplasmic surface of a subcellular compartment (3). Through these proteins, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion(1). Rab proteins contain conserved regions involved in guanine-nucleotide binding, and hyper variable COHO-terminal domains with a cysteine motif implicated in subcellular targeting. Post-translational modification of the cysteine motif with one or two geranyl groups is essential for the membrane association and correct intracellular localization of Rab proteins(3). Each Rab shows a characteristic subcellular distribution (4). In particular, Rab5 is ubiquitously expressed in human tissues. It localizes mainly to early endosomes, but is also present on the plasma membrane. It regulates the fusion between endocytic vesicles and early endosomes, as well as the homotypic fusion between early endosomes (5). Among the proteins recruited by the GTP-bound active Rab5 are Rabaptin-5 and EEA1 (6). Anti-Rab5 may be used as an early endosome marker.

纯度:

>90%

Accession #:

BC001267

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