Human Recombinant Tau-441 (2N4R) P301S Mutant Monomers (CHO-expressed, N-glycosylated)-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant Tau-441 (2N4R) P301S Mutant Monomers (CHO-expressed, N-glycosylated)

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-515E

规格：100 µg x5

目录价：￥25641

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Recombinant Tau-441 (2N4R) P301S Mutant Monomers (CHO-expressed, N-glycosylated)

别名:

MAPT, intracellular neurofibrillary tangles, NFTs, paired helical filaments, PHFs, 2N4R

产品描述:

Human Recombinant Tau-441 (2N4R) P301S Mutant Monomers (CHO-expressed, N-glycosylated)

反应种属:

Human

实验应用:

WB | In vivo Assay | In vitro Assay

纯化方式:

Affinity Purified and Size Exclusion

偶联:

N-term histidine tag & TEV site

产品浓度:

2 mg/ml or 5 mg/ml

表达系统:

Chinese Hamster Ovary (CHO)

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

48.609 kDa

存储溶液:

1X PB pH 7.4

产地:

加拿大

功能与背景:

Mammalian N-glycosylation is present on CHO-secreted tau 2N4R, which contributes to slower migration on SDS-PAGE than E.coli or Baculovirus/Sf9 expressed tau (1, 2). N-glycosylated tau has been identified in human AD-diseased brains, but not healthy brains, and may precede tau hyperphosphorylation (3, 4). N-glycosylation of Tau has been demonstrated to affect its aggregation propensity (5). The tau P301S mutation is associated with early onset neurodegeneration, and functionally reduces microtubule assembly and stimulates fibril assembly (6, 7). Our CHO-expressed Tau 2N4R P301S will readily form fibrils in the absence of heparin and contains mammalian post-translational modifications that may better mimic tau in human AD-brains.

纯度:

>95%

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